 flavonoids are natural substances found in fruits, vegetables, grains, bark, roots, stems, flowers, tea, and wine. They have beneficial effects on health and are used in nutraceutical, pharmaceutical, medicinal, and cosmetic applications due to their antioxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Research on flavonoids has received an added impulse with the discovery of their low cardiovascular mortality rate and prevention of CHD. Molecular docking and bioinformatics are used to predict potential applications and manufacturing by industry. The current review discusses trends in research and development on flavonoids, working mechanisms, functions, and applications, prediction as potential drugs for chronic diseases, and future research directions. This article was authored by A. N. Panche, A. D. Diwan, and S. A. Chandra.