 The trichothocene toxin deoxynivalinol, DON, is a prevalent and hazardous mycotoxin found in crops used for food and feed production with various plant and fungal derivatives of DON present in animal tissues. This review summarizes experimental data on the transport, detoxification slash metabolism and physiological impact of DON and its derivatives on intestinal, immune, endocrine and neurologic functions during their journey from the gut to the brain. This article was authored by Mark Moreska.