 A Candida oris outbreak has been occurring in Southern Nevada since August 2021. To investigate the outbreak, researchers analyzed more than 200 C. Oris samples collected from patients at multiple facilities. Three distinct lineages of C. Oris were identified from clades I and III. Additionally, open-source bioinformatics tools were developed and used to help with the epidemiological investigation. The researchers compared three different methods for C. Oris Hold Genome Analysis, Nullarbor, MycoSNP, and a new pipeline called the IUC. They also described a novel analysis method focused on identifying phylogenetic links between isolates within the outbreak. Finally, the researchers shared their findings with local and state health officials who used them to develop public health interventions. This article was authored by Andrew Grozowski, Frank J. Ambrosio, Lauren Mossick, and others. We are article.tv. Links in the description below.