 Nanoparticles, N-Piece, are excellent candidates for multiple applications due to their unique optical, electric, magnetic properties arising from the nanoscale, but their fast evolution and effectiveness in biological and biomedical fields are hindered by the behavior of nanomaterials in high ionic strength fluids and the formation of protein corona around N-Piece. Strategies to achieve stable N-Piece dispersions in high ionic strength fluids and anti-fouling strategies to avoid protein adsorption are reviewed. This article was authored by Luca Garini, Ramon A. Alvarez-Puebla, and Nicolas Pazos Perez.