 Welcome to this Elevator Pitch regarding reactive PKPD and our shiny application simplifying the PKPD review process. My name is Christopher and I've made this app in collaboration with my colleague Stephen Felgren. We both work at Nordisk. So first of all, a disclaimer, views and opinions expressed are those of the speaker and not necessarily Nordisk. So what is the idea behind this app? Well, for clinical pharmacology trials, PKNPD data is reviewed due to the limitations related to the previous use to assess PKNPD. Previously, a review was conducted by first creating a document containing the plots of the individual PKNPD profiles. Each reviewer then received a copy in which they wrote their own comments. After that, a review meeting was held to share and evaluate comments. And from there, some meeting minutes were created manually. The decision mentioned in these meeting minutes were then implemented in data. So this was a quite tedious process, which we have tried to simplify. So how does it work? This slide explains how a review is conducted in the application. So first of all, the host of the review uploads some data to the tool and then reactive PKPD automatically generates the figures of the individual PKNPD profiles. Then the reviewer can start and the reviewer can add their comments to the figures. And once a comment has been added, it is instantly shared with the other reviewers. Once the review has been conducted, a review meeting is held. And after that, the host of the review can download some meeting minutes based on the comments that has been added in the tool. Furthermore, the host is able to download a CSV file containing all the comments that has been added in the app. This CSV file can then be used to directly implement the comments and decision into the data sets. How does it look? This is the main PK display in the application. And let's have a closer look at some of the elements that you see here. So in the red box, you see two figures. The left one is the PK profile in a original scale, whereas the right one is in a logarithmic scale. Below these figures, you can see a yellow box. This contains the review comments for the specific and currently selected PK profile. And let's have a closer look at the figures and some of the features in here. So select and zoom. It's possible to select points in the figures by either double-clicking or by marking an area and then click within it. Then the selected points will be enlarged. It's also possible to deselect the points again by double-clicking elsewhere in the plot. It's also possible to zoom by marking an area and then double-click within it. And yeah, you can zoom out by double-clicking elsewhere, like deselecting the points. So this was some of the features related to the figures. Let's go back to the main PK display and have a look at some of the features that you see in the green box to the left. Here I've highlighted the three features here. The first one is the select profile, which is a drop-down menu used to indicate the currently selected profile, but also to swap between individual profiles. Below that, you can see a blue button, the add comment button. Once this is pressed, a window will show up and the reviewer can fill in their comments related either to data points or the whole profile itself. And once the reviewer has finished the review of the specific profile, they can press this profile review button, green button. And by pressing this, they'll be taken directly to the next profile in line. And furthermore, the app will keep track of their review progress. So these are the main three features that the reviewers focus on when they conduct a review in the tool. So it is a lot of the procedures related to the PGA and PD review process. That was all I had, so thank you for your attention and you can find more on the GitHub link below.