 Since February 2022, Malawi has experienced a cholera outbreak of greater than 54,000 cases. We investigated six cases in South Africa and found that isolates linked to the outbreak were Vibrio cholerae 01 serotypogawa from Seventh Pandemic L-Tor sub-linia JFR-15, indicating a new introduction of cholera into Africa from South Asia. This article was authored by Anthony M. Smith, Fudi Sequati, Linda K. Erasmus, and others.