 Abstract 2D layered materials with atomic thickness have attracted significant research interest due to their unique physical and chemical properties. These materials can be used as building blocks for creating heterostructures, which are composed of two or more layers of different materials. The heterostructure effect is the result of the interaction between the layers, leading to improved charge transport and increased efficiency in catalytic reactions. This review focuses on the synthesis, structure, and applications of 2D slash 2D heterostructures and heterojunctions in catalysis. This article was authored by Wansu, Guadonli, Exion Howley, and others.