 This study investigated the effects of heavy metal exposure on plants in two men, Russia. The results showed that the concentration of heavy metals was highest near the metallurgical plant with the highest levels of copper followed by iron, manganese, lead, and cadmium. The highest levels of phenols and flavonoids were found in coltsfoot while the lowest levels were found in red clover. The highest correlations between heavy metal concentrations and phenols and flavonoids were seen for copper, iron, and manganese. This suggests that these metals may be responsible for changes in the antioxidant defense systems of plants. This article was authored by A.S. Petikov, N.A. Kritikin, G.A. Petikova, and others.