 A typical skull-base osteomyelitis is a rare but fatal disease caused by infection of the ethmoid, sphenoid, occipital, or temporal bones that form the skull base. This type of infection does not have an otogenic cause, instead originating from the nose and perinazle sinuses. It can be difficult to diagnose and treat due to its rarity and complexity. In order to better understand and manage this condition, a comprehensive review of the latest research and expert opinions from multiple medical fields was conducted. This article was authored by Jura Urbancic, Domen Vosel, Saba Badalino, and others.