 So, nearly all biological databases are available to be downloaded as simple txt files. Sometimes we are interested to just download the database and do the analysis locally in our own machines that might save our time. Entrance is the integrated search engine which works behind NCBI. So, you are doing lot many researches you are looking for variety of data. So, on the back of it there is a system which they call it as entrance so that is there. It integrates PubMed and other 39 other scientific journals. It integrates between different protein databases and many other resources as we can see from here. It integrates between GEO which are the gene expression sets. We have seen them earlier, OMIM is online Mendelian inheritance in man. It interacts with genome databases, some taxonomy databases and in the middle we have the nucleotides, PubMed and protein databases. So, that is an integrated system which operates between different databases. So, you simply search for whatever you are looking and then entries will go and find it for you. Here is the page, entries you can put your whatever you want to search here in this box and then there are different connections which are available. So, we have literature resources, we have health databases, genomes, different gene databases, proteins and chemicals. So, sometimes we need to get the data in bulk amount and FTP is a good way in which we can get that data. FTP stands for file transfer protocol. Normally, we can use Linux for this purposes but for the window users there are some other packages or application programs available which they call them as FTP clients. So, we will probably use these FTP while we are doing some of our homeworks. So, once we get that data, most of the time we see that data is not in a proper format. So, softwares they require it in a different format. So, we might want to use some programming languages to help convert that data into the required format. So, Perl and Python are the biggest use in bioinformatics. So, these are the programming which are most frequently used. So, we conclude that data is transferred over the internet and data needs to be transformed or processed before giving it to different softwares.