 Neuroblastoma, NB, is a common form of childhood cancer that can spread to other parts of the body, such as the bone marrow. In this study, researchers examined the differences between the bone marrow of patients with neuroblastoma and those without it. They found that the bone marrow of patients with neuroblastoma was more similar to the bone marrow of healthy individuals than to the bone marrow of patients without neuroblastoma. Additionally, they identified specific genetic and epigenetic changes that occur when neuroblastoma cells migrate to the bone marrow. These findings could lead to new treatments for neuroblastoma that target the bone marrow environment. This article was authored by Vitas Vettahu, Wolfgang Esseskala, Rohit Nyansagar, and others.