 The tumor microenvironment is composed of various cell types, including cancer-associated fibroblasts, CAFs. These cells have been found to play a critical role in tumor development, invasion, metastasis, drug resistance, and other biological behaviors. Recent studies have identified distinct subtypes of CAFs with unique biomarker profiles, suggesting that each type may have its own specific function in tumor progression. This review provides an overview of these emerging CAF biomarkers and their potential implications for precision-targeted therapies.