 Laishmania species are the causative agents for leishmaniasis which is one of the neglected tropical diseases causing 70,000 deaths worldwide each year. Squalene synthase enzyme plays a vital role in sterile metabolism which is essential for parasite viability. The reported inhibitor showed the best binding affinity, minus 9.75 colchmoe, closely followed by ancystrotanzanine B and holemine. This article was authored by Padmika Wadanambi and Amonwele Frontoni.