 Previous studies have shown that the expression of MIR-211 is down-regulated in hepatocellular carcinoma, HCC cells. This leads to reduced levels of spark which is a tumor suppressor gene. As a result, HCC cells become more aggressive and invasive. To counteract this, researchers have developed a method to increase the expression of MIR-211 in HCC cells. This has been shown to reduce the proliferation, migration, and invasion of these cancer cells. Additionally, it has been observed that ectopically expressing MIR-211 reduces the levels of spark which further contributes to the suppression of HCC cell growth and metastasis. Therefore, MIR-211 could be used as a potential therapeutic agent for treating HCC. This article was authored by Biao Deng, Lei Yichu, Jin Fang Li, and others.