 Hi guys, this is Dr. Ahmed Ergen. I'm an endocrinologist and a diabetes education specialist I practice in Florida and New York virtually and Physically, I'm in Port St. Lucy, Florida and then we see patients physically in Port St. Lucy, Florida since I cannot be in multiple places. So in any rate today, we are going to talk about Rebelsis Rebelsis is on the TV. You guys are hearing about it. You're seeing about it and in my clinic patients are always asking Hey doc, you know, what about Rebelsis? Although they may be on a similar medication, but they don't know what it is So they ask questions and I understand that and the commercials can be very confusing You know, like you look at it at the end they talk about all this horrible side effects And you're like, oh my god, you know, I rather not do that But then you feel like desperate because you feel like you need a medication. Then what do you do? Ask your doctor. Good one. Alright, so you need to ask your doctor now If your doctor does not have enough knowledge, then you go to a specialist that will be people like me Doesn't have to be me, but then I know the knowledge is in your area If you want to do virtual visits, we do that as well for Florida and New York residents only Now I'm not here to promote Rebelsis again They are not paying or sponsoring this video by no means But my whole purpose is for you to make an independent decision because unfortunately Sometimes your doctor does not give you enough information. You're shy to ask Etc. Etc. I hope this video will serve that purpose so you can understand about this new medication Now Rebelsis is actually pretty much the same molecule of Osempic so you probably see those commercials about Osempic as well So what's the difference? Well, Osempic is the injectable form. It's injectable once a week Rebelsis is a pill on the other hand. So Rebelsis is a pill. Osempic is an injection. Osempic is once a week. Rebelsis is once a day We're gonna talk about the mechanism of action of this medication But before that I want you to understand the exact differences between the two injectable versus the oral with the Rebelsis you have to take it early in the morning You have to have an empty stomach and you have to wait at least 30 minutes after taking it with a couple Sips of water with the Osempic. There is none of that You just do once a week as small tiny injection. A lot of people actually in my clinic prefer Osempic over Rebelsis Just because of the convenience factor. That's once a week injection. If they already only some sort of injection They don't mind. They know injection is not a big deal. They're super tiny needle. Now Rebelsis is a pill for people who are scared of injections. Now, how do they work? Basically these are 95% similar to a gastrointestinal hormone made by your body. We call them incretin or GLP1 So the job of that hormone GLP1 Okay, or incretins So these are Hormones that are secreted by your gut when you eat food to tell your pancreas BAM pancreas right here. Hey, buddy makes some insulin We need insulin because this guy had some carbs and we got to take this Carbohydrates and sugar to the muscles so he can go work out not that he can go sit down. Okay, so That is the purpose of these Hormones to let your pancreas that there is food in your system now. What happens when you have diabetes? It's not just your pancreas is dead. It's not necessarily dead. These hormones are not doing their job So when you eat your body has no idea that there's food in your system So as a result, you know, you're eating on anything that oh my pancreas. It doesn't do anything, you know I think I need insulin. No, you don't need insulin. You need to fix these hormones first Okay, so you need to fix this hormone. So your pancreas is informed that there's food in your system now It's interesting when they do studies, you know these medications the JLP one on Incretin's Incretin mimetics we call them because they're mimickers mimetics is like a mimicker So your buddy doesn't know the difference. So when you give the medication, you know, and there's food it alerts the pancreas So what happens is, you know, when you take these medications your insulin boosts up so Much so much in a good way because your body makes insulin only when you need Unless you are on other agents such as gulliposide, gliburide or gullipuride or any type of insulin You do not have a high risk of low blood sugars from this because you know Your pancreas stops working when your blood sugars are below 90 milligram per deciliter So With that, you know, it's very safe. It's very safe But of course there are side effects which we'll talk about when I say very safe not necessarily It's not side effect free But they are in a good way because like they don't cause weight gain to actually help with the weight loss because they Make you feel full which is one of the side effects of this medication You feel full so you cannot necessarily finish your plate or your sandwich or whatever you're eating So you're gonna be able to have much less food and you're gonna be able to fast for a long time Let's say you're on metformin or dysmedication Okay, then you can really go for a long fast without having to worry about having a low blood sugar Now it can still happen occasionally in a rare patient But typically in most patients low blood sugar does not happen when you are on agents like this Unless you're on another agent that does that such as we talked about something really our insulin Then you know instead of stopping dysmedication what we end up doing is we end up cutting back on those sulfonylureas and Insulin and that way, you know, we are able to reduce those medications that causes weight gain and low blood sugar Or eliminate them actually it's not uncommon, you know, we do this all the time My goal in my clinic is to get people off the insulin to get people off the sulfonylurea agents such as gulipazide Glyboride glima pride because they cause weight gain they cause low blood sugar. They're not fun Again, we do dietary approach, but we use the right medications to get the job done We also have our own supplement now, which is great The reason we came up with this supplement is a lot of people cannot afford these medications, you know That's rebalances is like six hundred bucks or something and the ozampic is like eight hundred or nine hundred dollars Sometimes people literally come and yell at me like dog. What are you doing? Are you trying to you know, empty my bank account? I'm not look, you know, I'm not I'm not in charge of these drugs You know, they do their own thing. It's all about regulations. They have to spend billions of dollars to a Satisfied requirements legally, you know the FDA requirements, la da da da. It's a lot of work for on their side And they have to make their money. So but I'm here. I'm the doctor I'm just trying to choose the best one for you But on the other hand we tend to forget the power of the nature I used to be one of those guys who will say oh supplements don't work Don't try whatever only stick with these but then I start opening my mind to my patients listening to my patients And realize there's some of these supplements work not all of them But some of them work and it is hard for you to guys to cherry pick. So I said, you know, why don't I do that? I can choose cherry pick those medications or the supplements for these people who cannot afford these expensive medications Or their insurance doesn't cover it or they don't want to get into this because you know There's labels about them like cancer label, da da da da, you know, and we'll talk about it in a second But the people get scared and from these medications. So sometimes you just want to go natural and for those people We created this sugar MD advanced glucose support after years of listening to my patients I came out with a formula that will bring your blood sugar down. So back to the rebellious though I mean, they're good drugs as I said, you will also when you look at the commercials You will hear things like oh, well, it can if you have cancer in your family Don't take this drug. Don't take rebellious if you or your family ever had medullary thyroid cancer You know, listen to that carefully though, you know, they're talking about a very specific cancer, which is medullary thyroid cancer It's not a thyroid cancer. It's a medullary thyroid cancer Which is super rare from a thyroid cancer and you know, I'm a thyroid specialist too And I see those cancers like once in a blue moon is not that not like common even with these medications being widely used And also they talk about pancreatic cancer if you have a first-degree family member with it Now on the other hand though the studies do not show the human studies do not show increased risk of cancer If that was the case FDA would never allow this to be on the market in animal studies in red studies though some rats develop these cancers and The mechanism is not well explained, but what we are trying to do here I think it's mostly dose-related and some of these rats are prone to it So, you know, the rats versus humans are not a direct match So as a result, definitely if you have a family history of medullary thyroid cancer or pancreatic cancer Avoid them. If you don't, I don't think there's too much to worry about So I've been using these drugs for 10 years now since they came to the market and they have been safe and effective As I said, expensive. Yes side effects. They can cause increased satiety. They can cause nausea Some people vomit from it. So if you're vomiting, don't stay on this medication If you're nauseous, it tends to go away if you can't put up with it Some people use ontinozic medications for a while, but generally the side effects last a few weeks Diarrhea can happen. Diarrhea sometimes sticks around for a long time. It's not a fun side effect as well So especially if you're a methroman already suffering from diarrhea approach with caution to these drugs As I said, they are effective when they work people love it when it causes side effects people hate it So I guess, you know, you can definitely try They are definitely better than a lot of other medications better than insulin better than South Carolina Urias That is what I'm gonna say today. So guys if you liked the video Make sure you write a comment ask questions and we will try to answer all your questions and make sure you share this video I'll see you later