 The ethics checklist aims to promote careful design and execution of research in deep phenotyping psychiatric research by requiring researchers to give reasons for their decisions related to ethical, legal, and social implications, ELSI, issues. It is composed of 20 key questions subdivided into six interrelated domains, informed consent, equity, diversity, and access, privacy and partnerships, regulation and law, return of results, duty to warn and duty to report. The ethics checklist is intended to address regulatory gaps, inconsistencies across research teams and ethics protocols, and a lack of consensus among institutional review boards on when and how deep phenotyping research should proceed. This article was authored by Francis X. Shin, Benjamin C. Silverman, Patrick Monette, and others.