 The 2019 coronavirus COVID-19 has caused a global pandemic with no known effective treatment or vaccine yet available. The virus is believed to have been spread through contact with infected individuals, but it is also possible that the virus could be transmitted via airborne droplets. In order to prevent further spread of the virus, there is an urgent need for a safe and effective vaccine. However, the development of such a vaccine may be complicated by a phenomenon called antibody-dependent enhancement, ADE, which can occur when certain antibodies are present during infection. These antibodies can actually make the infection worse, leading to more severe symptoms than if the same person had not been exposed to the virus beforehand. This phenomenon has been observed in other viruses, including SARS-CoV-1, MERS, HIF, Zika, and Dengue, and can lead to increased mortality rates in vulnerable populations. To address this issue, researchers are looking into ways to identify and neutralize these antibodies, as well as developing vaccines that do not contain any ant. This article was authored by Jiang Wang and Martin S. Sand.