 In this study, researchers examined the effects of nemenpic type C, NPC, on the development of Perkins cells, PCs. They found that NPC causes significant changes in the structure and function of PCs during postnatal development. Specifically, they observed reduced levels of mitochondria and lysosomes in the developing dendrites of NPC affected PCs. Additionally, they discovered that these cells are subjected to both anabolic, MTORC1, and catabolic, TFEB, signaling, which leads to a loss of metabolic balance. This imbalance is further exacerbated by the activation of the MTORC1 pathway, while the TFEB signaling pathway is suppressed. These findings suggest that the disruption of lysosomal metabolic signaling in PCs may cause dendritic and synaptic developmental deficiencies that lead to early degeneration of PCs in NPC. This article was offered by Sarah Kim, Kathleen Ochoa, Sierra E. Melly, and others.