 Artificial intelligence, AI, has the potential to revolutionize healthcare, but its use can also lead to serious risks to human health and well-being. Misuse of narrow AI can increase opportunities for control and manipulation of people, enhance and dehumanize legal weapon capacity, and render human labor increasingly obsolete. Self-improving artificial general intelligence, AGI, could pose an existential threat to humanity itself. To mitigate these risks, we must develop effective regulations, including the prohibition of certain types and applications of AI, and call for a moratorium on the development of self-improving AGI. The medical and public health communities should engage in evidence-based advocacy for safe AI, rooted in the precautionary principle. This article was authored by David McCoy, Frederick Fedderspiel, Ruth Mitchell, and others.