 Here everybody, Dr. O'Hare, we're going to continue on with our series of the protein synthesis inhibiting antibiotics. So just a reminder that we're going to talk about the macrolide antibiotics today, very very important ones. So they are going to impact the 50s ribosome primarily. Let me go ahead and show you. So the macrolides, they were first discovered in I believe 1952. They found them in the streptomyces, which is very common. About half the antibiotics that exist today come from that streptomyces family. But it was streptomyces erythrius, I believe, so 1952. The first one discovered was erythromycin, so we can talk about that. But the really, really important one is going to be azithromycin. But first, how they work. So these are these really large complexes, and they gum up the works basically as you're making new proteins. And certain combinations of amino acids can't actually form as long as this drug is present, which means that you're going to stop protein synthesis. Because if you can make, you know, protein synthesis will halt that there's any one combination that can't be used. So it is going to inhibit protein synthesis. These would be bacteriostatic drugs. So I talked about when it was discovered the erythromycin is an important antibiotic, but it's only useful against gram positives. It isn't as broad spectrum because it can't enter gram negative bacteria the same way that azithromycin can. So let's talk about this one because azithromycin you've probably heard of it. It's the Z-PAC, right? The advantage of azithromycin, much more broad spectrum than erythromycin, but the real advantage is it's half life. So if you compare the two, erythromycin has a half life of one and a half hours. And azithromycin or the Z-PAC formulation would be 68 hours. This means that you can take one dose a day and the Z-PAC is what, three days? So a total of three pills, whereas with other antibiotics, you're taking pills every few hours and for a much longer period of time. So azithromycin or the Z-PAC formulation, super important because of that. Every time you ask a patient to take another pill, there's the chance they're not going to take it and the longer the treatment takes, the same kind of thing. So the short, sweet treatment protocol that the Z-PAC gives us is very important. So we have a broad spectrum antibiotic. It is effective against gram negatives, unlike erythromycin. And then that sweet long half life is what gives the Z-PAC such a good advantage. All right. So those are the macrolide antibiotics, including erythromycin and azithromycin, the Z-PAC formulation. Have a wonderful day. Be blessed.