 So this is a very typical scenario we see in clinical practice where you have a patient 74 year old male presenting with cognitive decline going on for the last two months and memory loss as well as some speech difficulties. And MRI brain, as you can see, we have different sequences, FLIR, T2 post contrast showing you a very ugly necrotic enhancing mass with a lot of swelling and edema in the right cerebral hemisphere and also has some areas of restricted diffusion in the solid part. And if I have to show you the perfusion maps, it's very vast or you can see the blood volume is markedly increased in the solid enhancing part of the tumor even over here. One of the things I struggle with is trying to exactly localize where this enhancing necrotic mass is just based on the axial images and that's where I would suggest that everybody should look at the sagittal reconstructed images. And those are very helpful to decide. For example, based on the information I get from the sagittal images you can see that this tumor is actually in the temporal lobe only. It's not involving the frontal lobe, probably going a little bit into the insula over here, but definitely not involving the frontal lobe. All the edema and swelling is in the temporal lobe. And this is what we typically see with primary de novo GBMs. The reason I would like to call this a primary de novo GBM IDH wild type is because of the age, more than 40 years, this patient is 75 and presenting with subacute neurological deficit. Now we also know that these tumors are really bad tumors to have and this is what happens. This is a scan done a year and a half. I'm not showing you all the follow ups. This patient did undergo all the therapy regimens available, including surgery initial debulking, followed by standard stoop regimen and even a vastan therapy for the recurrent tumor. But you can see the tumor is clearly increasing in size. It's progressive and this unfortunate patient ended up dying after 20 months of the initial diagnosis.