 This study found that liver transplantation, LT, has a better prognosis than liver resection, LR, in patients with intrahepatic cholangiocarcinoma, ICC. Patients who underwent LT had a higher five-year overall survival rate than those who underwent LR. Additionally, patients who received neoadjuvant chemotherapy prior to LT had a significantly higher five-year overall survival rate than those who did not receive it. These findings suggest that LT may be a viable option for patients with ICC, although more studies are needed to confirm these results.