 We have developed a strategy to design and evaluate high-entropy alloys, HEAs, for structural use in the transportation and energy industries. The strategy involves creating palettes of elements to meet target properties of each HEA family, building HEAs from these palettes, and using a three-step process to screen and evaluate a large number of HEAs. This process includes high throughput computational calculations and experiments to determine phase equilibria and mechanical properties. This article was authored by Daniel B. Miracle, Jonathan D. Miller, Oleg N. Senkov and others.