 The study describes a case of multiple Clostridioids difficile infections caused by three isolates with different morphotypes on solid media. The genomes of these isolates were sequenced and compared to seven reference strains, revealing horizontal gene transfer events that contributed to the adaptation of the species. Within the multiple infection of a single patient, genetic material was exchanged between the isolates, resulting in higher genome variation than the observed single nucleotide polymorphisms. This article was authored by Uwe Gross, Elsebite of Brzezyskiewicz, Katrynganka, and others. We are article.tv, links in the description below.