 In this study, we found that a 14-day VPZ-containing triple therapy was safe and more effective than other treatments in the Chinese population. Additionally, VPZ did not have any direct inhibitory effects on H. Pylori but instead worked indirectly by down-regulating genes related to the ribosome. This suggests that VPZ could be used as a first-line treatment for H. Pylori infection in the Chinese population. This article was authored by Zinan Zhang, Zinan Zhang, Fan Lu, and others.