 This research has revealed that smooth muscle cells are present in the meniscus from early developmental stages through adulthood. These cells express notch 3, which is a key regulator of cell differentiation and proliferation. When these cells are inhibited, they can reduce the production of collagen eye, which is associated with fibrosis. Additionally, notch 3 inhibition can also reduce the effects of transforming growth factor beta, TGF beta, and connective tissue growth factor, CTGF, both of which are known to cause fibrosis. As such, notch 3 may be a promising therapeutic target for treating meniscal fibrosis. This article was authored by House Sun, Fumjolu, Jinsun Lin, and others.