 This research examined the role of monocyte populations in the development of cardiovascular disease, CVD, and individuals living with HIV. It was found that persistent inflammation caused by HIV can lead to increased levels of circulating monocytes, which contribute to the development of CVD. Additionally, it was discovered that the presence of subclinical CVD amplifies the gene expression signature of monocytes, suggesting that these cells could potentially act as a reservoir for HIV replication. This article was authored by Juan Lin, Eric Ehinger, David Bihena, and others.