 CLN3 is a protein involved in the transport of lysosomal enzymes from the Golgi apparatus to the lysosome. Mutations in this gene cause baton disease, a rare and fatal form of neurodegenerative disorder. In this study, researchers found that CLN3 is essential for the proper sorting of lysosomal enzymes and the formation of lysosomal tubules, which are necessary for autophagy and the reformation of lysosomes. This suggests that CLN3 plays a key role in the regulation of lysosomal function, providing insight into how baton disease develops. This article was offered by Alessia Calcagni, Leopoldo Stiano, Nicolina Sampelli and others.