 In Pakistan, Beta Thalassemia is a serious health concern with an estimated 5-8% carrier frequency, and birth of 5,000 major children every year. The treatment of Beta Thalassemia major patients poses a great economic burden, thus making it important to focus on prevention services. Currently, there is only one government-funded program in Punjab province called the Punjab Thalassemia Prevention Program, which provides free-of-cost services for Beta Thalassemia screening and prenatal diagnosis. Screening is done through complete blood count and hemoglobin electrophoresis, while chorionic villi sampling and amplification refractory mutation system, ARMS, are used for molecular diagnosis. Molecular techniques such as non-invasive prenatal diagnosis and preimplantation diagnosis are also being trialled. This review discusses the current diagnostic facilities and the status of prevention programs in Pakistan, as well as potential future perspectives. This article was authored by Mahmood Gaffer, Mohamed Farooq Sabar and Furqan Sabir. We are article.tv, links in the description below.