 The study examined the role of the LNCI in a NEET-1 in regulating the expression of epithelial transcription factors during epidermal differentiation. It was found that NEET-1 is involved in the repression of the transcription factor NP63, which is essential for the maintenance of normal epidermis structure. This repression is mediated through the recruitment of the histone-de-satellase HDAC1 to the promoter region of NEET-1, leading to its decreased expression. In addition, NEET-1 also interacts with the promoters of other important epithelial transcription factors, such as KLF4 and FOXQ1, which are necessary for the proper formation of epidermal layers. Taken together, this study provides new insights into the mechanisms underlying the regulation of epithelial differentiation and the importance of NEET-1 in the process. This article was authored by Claudia Fierro, Veronica Gatti, Veronica La Banca, and others.