 Nanoscale silver, nanosilver, has been used in various products and applications due to its antimicrobial properties. However, there have been increasing concerns about the potential health risks associated with its use. This review provides an overview of the current understanding of the toxicity of nanosilver, including its effects on cellular processes, its ability to induce oxidative stress, and its potential to cause genotoxic damage. It also discusses the challenges associated with studying the toxicity of nanosilver, including difficulties in characterizing the particles and understanding their behavior under different conditions. Finally, it suggests ways to improve our understanding of the toxicity of nanosilver by providing guidance on how to conduct experiments and interpret results. This article was authored by Assault Lynch, Kenneth A Dawson, Andreas Lutch, and others.