 The novel coronavirus, NCOV, commonly known as COVID-19, has caused global pandemic since its emergence in December 2019. Despite extensive research efforts, there is no effective cure or vaccine available yet. This paper proposes the use of synthetic peptids derived from the S-protein of NCOV as a potential therapeutic agent. The peptids were tested on human macrophages and zebrafish larvae, and their effects on cellular responses and inflammation were evaluated. The results suggest that these peptids can effectively block the interaction between the virus and the ACE2 receptor, thus preventing the spread of the virus. Furthermore, they induce an inflammatory response in both cells and animals, similar to what occurs in humans during the acute phase of the disease. Thus, these peptids could potentially serve as a viable alternative to treat COVID-19. This article was authored by Tai Sibioni Bertibostos, Andrei Guillemi Portella de Paula, Rebecca Boso dos Santos Luz, and others. We are article.tv, links in the description below.