 Abstract immunotherapy is an attractive treatment strategy for cancer, but it needs to be improved. A new nanopotentiator has been developed that can combine chemodynamic therapy, CDT, and sonodynamic therapy, SDT. It works by blocking adenosine metabolism, generating reactive oxygen species, ROS, and triggering immunogenic cell death, ICD, and sting-mediated signaling pathways. This combination of treatments leads to more effective immunotherapy, resulting in better tumor control. This article was authored by Mei Xiaoshan, Fuxua Wang, Yao Lu, and others.