 A novel series of chlorine E6 curcumin derivatives were designed and synthesized. These compounds were tested for their photodynamic treatment, PDT, efficacy against human pancreatic cancer cell lines. The compound with the highest activity, 17, showed high cellular uptake and induced apoptosis in the cells. Furthermore, it was found to be effective in reducing tumor growth in melanoma mouse models. This article was authored by Til Bahadur Tapamagar, Ju Suk Lee, Ji Hong Lee, and others.