 This paper discusses how cerium oxide nanoparticles, CO2NPs, can be used to treat cancer cells with mutated TP53 genes. The authors found that CO2NPs are able to increase reactive oxygen species, ROS, levels in these cells, which leads to the degradation of mutated P53 proteins. This degradation prevents the gain of function, effects caused by the mutated protein, such as increased cell proliferation and migration. By using this method, the authors were able to reduce the size of tumours in mice models of TP53 mutated cancer. This article was authored by Hao Zhong, Wang Zhong, Wuchuan Hu, and others.