 This study investigates the role of small extracellular vesicles, CEV, derived from CCR2, positive macrophages in promoting cardiac repair following an acute myocardial infarction, AMI. The researchers found that these CEV can be used as a therapeutic agent to reduce inflammation and improve cardiac function. They also discovered that these CEV contain microRNAs, mRNAs, such as MIR-181B5P, which play a key role in regulating the production of glucose by macrophages and reducing oxidative stress. Blocking MIR-181B5P impaired the ability of CEV to reduce inflammation and improve cardiac function. This study suggests that CEV may provide a novel approach to treating AMI. This article was authored by Lonley, Jiao Song Chao, Xing Li, and others.