 Thank you all for joining us today. It's great to look out there and see all these familiar, friendly, and helpful faces that have really helped us to get where we are today. I'm gonna, just in the next 10 minutes or so, I'm gonna try to frame the afternoon a bit and try to frame a little bit about, give a little sense of where we are, where I think we are in terms of the CTSI. So this is a tale of summer, I think. Well, you'll see why on the slide number one. So I've just come back from summer vacation. I grew up in Colorado and went back to see my folks and brought my kids with me and we had a great trip. And my folks belong to the, as probably many of grandparent-age do, belong to the Historical Society of Colorado, and so they decided we should ride this historical train that connects Georgetown to Silver Plume, Colorado. And how much do you know this train? And I had done it as an adolescent and thought it was horribly boring. But now that I'm a little older, I actually really enjoyed the trip and our kids who are eight and six also really love the trip. So you can see there's a, you know, they're age-appropriate in this for trips like this. And my son asked this question, Daddy, why does the train stop here? And I'm going to use this to talk a little bit about where we are now. So this train, this is a train that connects the two and it goes over this gigantic bridge to do a loop in order to get down this big incline. And it got me interested in, you know, what is this train doing here and what really is the history of the train? This actually I do think is a nice metaphor for where we are, what our job is in CTSI. And so now I'm just going to take you very quickly and in a sort of not very educated way through an evolution of an industry, in this case the railroad industry. In that railroad industry definitely started just as we did in CTSI with a startup in a build phase during which they had to bring people on to get the job done, build the basic structures to get things moving. They started slow, but they were able to accelerate and for them a lot of this was driven by by the migration and the migration was initially largely driven by mining. So mining, like the basic discoveries of our day, the basic science discoveries, mining was their basic discovery and they needed infrastructure in order to support the discovery of minerals and then the mining of it. So this in 1857 is what the western states look like. You forget just how bizarre things were, how undefined things were back then. But look at California. We were actually smaller, but then one of our boundaries hadn't even been defined because Arizona wasn't there yet. Nevada was a weird sort of squarish looking thing. I mean, it was totally different. This is also showing, and it's hard to see, a few railroad lines. There's some smudges on here for proposed new railroad lines, but there were very few railroad lines in 1857. And then so how did this come about? Well, it ends up that there was an investment here. So for them, the investment was almost all outside the US. It was only later that US industrialists got in the mix. It was mostly venture capital equivalents from Europe that invested in the mines and in the trains. For us, of course, it's been NIH largely and we're fortunate to have several folks from NIH, including our program officer, Rosemary Filart, who's here somewhere. Yeah, so thank you. But we also are fortunate to have our other investors here too, which are really the institutional leaders. So we've had a tremendous amount of investment from the chancellor's office, and thanks, Jeff, for coming, and also from all of the dean's offices. We've also had investment from our partners, and we've got partners here that are well represented. And recently, we've had investment more and more from industry and other partners. So the next thing that you need in order to get things started is the people to get the job done. This is just a picture of a group that had just completed a new rail line. Wonderful that they took the picture of absolutely everybody in the team here. If we could try to take a picture of this group today, I guess it wouldn't. I don't think it'd come out as good as this one, though. And for us, this has been a lot of work, getting the right team together. But I think we've really been able to do that successfully, particularly in the last few years. We had great work from the founding team who really got us to where we are. And then over the last couple years, we've had some nice transitions to, I think, a more permanent team who, let me just quickly say in this last year, that includes Sally Mead, who's come on as director of our administration. And Brenda Jacobson, who's the executive director for CRS. June Lee, who's come on to lead early translational research. She'll hear more from her later today. And then Minnie Kalin has stepped up into a new role as the deputy director for CTSI. And we've had many, many others join, but I obviously can't. I'm not going to be able to mention everybody today. And then Paul Boeberding has joined our board as well. So that's a nice addition, too. So those are the workforce. And of course, we've got to develop new workforce, too. The new miners, the new engineers. Infrastructure is another key thing that we've been trying to build. And I love this picture because, boy, does that bridge look unsafe. And I would say that some of our infrastructure feels as unsafe and unstable as this railroad bridge, but yet it has been really important to accelerating the pace of the work that's done around here. So I, over time, you want to build this up. But this infrastructure includes things like clinical research services with all the centers that we have there, the consultation service. Even our small grants program could be considered falling into this. So by 1870, this was the network of train routes in the US. And this was very rapidly increasing over time. And you can see, particularly in the Pacific states, in the Western states, these are total railroad miles that rapid, rapid increase in the late 1800s. And this is a picture of that train that I showed you before on the bridge that I rode with my two boys. And it's a totally different place now. They chopped down every single tree in this whole valley. This is now, you know, has these big tall pine trees, spruce trees everywhere. There's no real, there are only dirt roads in here at this point. Now the highway actually runs through here. I-70 runs through here. So it looks totally different. And this was actually an incredibly successful mining area. Over 15 billion dollars, today's dollars were pulled out. So this is like, this is a huge investment by these European investors. You needed a train to haul the people, to haul the ore back and forth. And this is the peak of railroads in the US, 1918. And you can see now that network I showed you before, it's, you can make out the old lines if you compare them side by side, but wow, there were a lot of trains. A lot of trains going everywhere, taking people everywhere. And of course, 1918, this is right at the point at which automobiles were becoming popular. During that time, there's a great evolution in the trains as well, from, you know, very early trains to much more rapid trains. And for us, you know, the small grants help us to do that. Global health and what it does helps to do that. Also our partnerships with other institutions on campus like IRBs and contracting office and all of that helps to do that too. Okay, so now I'm moving on to reality, two minutes left. We're going to keep everybody on time, so me especially. So on to reality. So I'm going to show you just really quickly some achievements that won't show up in anybody else's presentations, but just, these are broad and related to sort of where we are, how we're in our summer now. So industry sponsor clinical trials, this is thanks to Jim Caracus as in office, those have increased over time and we've seen a rapid decrease in the amount of time it takes to execute these agreements. And this actually under-represents how much change there's been because a lot of that change occurred even earlier. And it may have begun at this retreat three years ago when there was a big outcry that this was a major problem and that needed to be dealt with. IRB approval times, and this is, these are data from John Helden's group, went from 139 days in 2009 to 71 days in 2010, so I mean that's huge. For CTSI broadly, yeah, these are big deals. For CTSI broadly, we've seen a much larger number of investigators using our services. We've also seen a rapid increase in the number of publications. We don't have this year's data yet to show you. And then K grants on campus, including the ones we sponsor but also the other ones that we've helped people to get through our training programs and other support mechanisms and mentoring have doubled to since 2006, so really pretty dramatic change. And we've also become financially more responsible. So this is an increase in our recharge revenue which has continued to increase and must continue to increase further as we go forward. And, you know, we can't completely take credit for this, of course, but it's nice to see that UCSF is consolidating its position in number two for NIH funding and closing in on number one, which is Hopkins. And we hope this will continue. It looks like most of this is related to more on the clinical and translational end of funding than the basic, but, well, again, this only goes through 2009. So I haven't addressed a question, you know, that I was asked, Daddy, why does the train stop here? Well, it ends up the train stops in a dusty parking lot. It's not even in town. It's not in any of these towns. It just stops. And so the question was, why would the train stop there? Well, this was 1918 and this is 2006. So the train system has really been dismantled. We all know this, of course. And I think this is an important lesson for us, too, that we need to be thinking about how things are going to change in the future. Yeah, it's great. We built this wonderful infrastructure. We've really come a long way in five years, but things are going to change. We need to have our eyes open to what's around the corner. And I think there are some warning signs there. Today, especially, one might feel uncertainty about the future, particularly financially, and that really can impact us. And so we need to think about a sustainable plan for the future. Now, of course, with the dismantling of trains, the interstate system came about, and that has its own advantages and disadvantages, as we know, but also there is a return to trains. And in fact, in that very valley that I showed you, there's a, they're considering reopening a train route, not for miners anymore, but for skiers and mountain climbers and all of that to connect Denver to the mountains because the auto traffic has gotten so bad. So in evolution of an industry, there's a building phase. It's a kind of a crazy hectic phase. You put the infrastructure in place, you've got to hire the people, and then there's a sustainability phase. That's where we are now. We've got to prepare for change, keep our eyes on the future. We've got to consider more flexible approaches that can change over time and also are flexible and responsive to the needs of our users, right? And that's a lot of what we're doing now is to become more responsive. Responsive force us all, encourage us all to be more responsive to the needs of our users. And we have to continue to innovate or we will go the way of the rails. Okay, so with that, we've got a great afternoon. It's really about celebration. Last time we did this a year ago, we had to focus on what's gonna be in our renewal. We know that now, and fortunately we have our renewal. And we were really lucky to, yeah, thanks to all your hard work. And we were really lucky to not have any significant cut in our budget, which is quite unusual for other CTSAs. So we want to celebrate that for a bit. And that's what the CTSIDEL is all about. It's a way to get in, allow all the programs to present their shining moments and to put those in the context of what's going on in the university with our judges in a short period of time. And then you can see the other things that we have in store for you this afternoon. So with that, I'm gonna invite up the judges to the front and we're gonna launch in our experiment. So the judges today, and I can't tell you who's Paula and who's Simon. Yeah, maybe. But we'll see how that pans out. But the judges are Sam Hogwood, who's the Dean of the School of Medicine. Talmadge King, who's the Chair of Department of Medicine in David Vlahoff. So thank you all for as a Dean of the School of Nursing. Thank you for doing this. And I get to be the Ryan Seacrest of the meeting and we do, because we have so many of these presentations to do, we're gonna be pretty strict about keeping to the time. So they have about, except for two programs, they have five minutes to present and then we'll have about five minutes to discuss. We may have a time for one question or one comment from the audience for each one, but we'll have to sort of see how that goes. So with that, I will invite up the first group.