 This study examined the impact of safer supply programs on injection practices in Ontario, Canada. The results showed that these programs had a positive effect on injection practices, including decreasing the amount of fentanyl used and increasing the use of hydromorphone tablets instead of fentanyl. Additionally, participants reported stopping injecting altogether and taking safer supply medications orally. These findings suggest that safer supply programs can be effective in reducing injection-related health risks, in addition to overdose risks. This article was authored by Merylou Gagnon, Catherine Radzinski, Adrienne Guter, and others.