 Photobiomodulation, PBM, also known as low-level laser therapy, LLLT, is a non-invasive treatment that uses light energy to promote healing, reduce pain, and decrease inflammation. It works by stimulating mitochondrial activity, increasing ATP production, reducing reactive oxygen species, and regulating calcium levels. Additionally, it can activate NF-Kappa-B in normal quiescent cells, but it activates it in activated inflammatory cells. This leads to reduced inflammation, which is especially beneficial for conditions such as joint pain, trauma, lung diseases, and brain disorders. This article was authored by Michael R. Hamblin.