 � Gibi ৈ다 ��� ৗ র ඈ ই ��� র ಈ র র. র র র র র র. ব র র র ব র র র র র র র. of differentiation and midline cleavage of proson kefalon or forebrain during embryonic life. Classically hollow proson kefalon has been divided into three subcategories on the basis of severity of malformation allobard, semilobard and lobard. These three types affect ventral proson kefalon severely. Another variant of proson kefalon which affects the dorsal proson kefalon severely is known as syntelen kefalon. In practicality the hollow proson kefalon represent a continuum of forebrain malformation with no clear distinction among the different categories. Case report. The patient was referred on day 2 of postnatal life from a sub-divisional district hospital to pediatric medicine emergency of NRSMCH, singular antinatal ultrasound assessment done on 3rd trimester of gestation, revealed diagnosis of micro kefalon without mentioning any structural malformation of brain or face. In NRSMCH the patient underwent ultrasound screening of brain followed by MRI brain. Imaging findings. As the patient was diagnosed with congenital micro kefalon, developmental brain anomaly was suspected as a possible cause for which the patient underwent USG screening of brain. However the USG screening the patient underwent MRI brain assessment to corroborate the ultrasonographic findings and to find out any other associated anomaly. USG and MRI findings have been described in the following slides. USG brain. Coronal sonogram shows non-visualization of vaxerebrae anteriorly, incomplete inter hemispheric fission, fused frontal lobes and partial fusion of thalamine. In the next slide USG brain images shows non-visualization of corpus callosum at midline. In the next image of USG brain mono ventricles with developed temporal horn noted non-visualization of septum pelusidum is also noted. In the next slide of MRI brain axial section of brain shows anteriorly fused frontal lobe with absent inter hemispheric fissure, no intervening fuxerebrae noted in anterior part of forebrain, at posterior part of forebrain inter hemispheric fissure noted with intervening rudimentary fuxerebrae. The next slide both figure 5A and figure 5B shows at the anterior part of cerebral fused frontal lobes inter hemispheric fissure is not well formed no fuxerebrae visualized as well. In figure 5C posteriorly occipital lobes of cerebral hemispheric are divided by visible inter hemispheric fissure and ill-defined fux. In figure 6A it can be seen lateral ventricles are continuous at midline forming mono ventricle with partially developed occipital and temporal horn, absent septum pelusidum and rudimentary third ventricle are noted as well in figure 6A. In the next image of MRI brain the in the sagittal section at midline in anterior part no corpus callosal tissue noted, but posteriorly remnant of corpus callosal tissue noted suggesting partial corpus callosal agenesis. In the next slide figure 8A shows there is decreased number of sulky and gyri in brain parenchyma suggesting patchy gyria. In the figure 8B absent olfactory tracts and bulb noted. In the next image of facial anomalies figure 9A shows cleft lip and cleft palate and in figure 9B mild hypotelorism noted. From the imaging findings of USG and MRI brain it can be concluded that this is a case of semilover hollow proson kefaly with partial corpus callosal agenesis and patchy gyria. Associated facial anomalies like cleft lips and cleft palates are noted as well. Discussion hollow proson kefaly is a complex brain malformation affecting both the forebrain and the face. It is estimated to occur in 1 in 16,000 light bars and 1 in 250 concept assess. Between the 18th and 28th day of gestation the anterior portion of the neural tube the proson kefalon divides into two parts telene kefalon and diene kefalon. These parts then undergo a cleavage under normal circumstances these would result in a telene kefalon and diene kefalon divided into two half seeds incomplete cleavage of the proson kefalon results in a brain malformation known as hollow proson kefalon. Hollow proson kefalon is the only brain anomaly described in which the posterior corpus callosome forms in the absence of any anterior callosal formation. As the spectrum of hollow proson kefalon is observed from the most poorly differentiated allobar brain to the most differentiated lobar brain a gradient of development is seen in which the separation of the hemisphere, development of the fox cerebrum and development of the cerebral hemisphere progress from the occipital pole of the frontal from the occipital pole to the frontal pole of the cerebrum. The anterior extent of the corpus callosal development correlates with the anterior extent of inter hemispheric fissure formation and can be used as an approximate marker of brain development in hollow proson kefalon patients. In other words the further anterior corpus forms the better developed the brain. Diagnosis of hollow proson kefalon is usually made prenatally in omen by antinatal USG. In this case however diagnosis is done postnatally hollow proson kefalon prognosis remains generally poor with the type of hollow proson kefalon and coexisting craniofacial anomalies as key prognostic indicators. For instance less than 20 percent of patients with allobar subtype will survive 12 months while approximately 50 percent with the isolated semi-labor form will survive beyond 1 year. In conclusion of hollow proson kefalon although mainly supporting it requires a multidisciplinary approach aiming at managing symptoms and complications and avoiding added disability to improve the overall quality of life. Conclusion in conclusion hollow proson kefalon is a rare structural anomaly of the brain with a complex and multifactorial etiopathogenesis. It is prudent to diagnose it prenatally classify its severity and forge its prognosis so that parents are counseled early enough to make informed decision specially where termination of pregnancy may be implicated.