 This study investigates the role of LNCRNA-ZNF667-AS1 in rheumatoid arthritis, RA, progression by examining its effects on cell proliferation and inflammation in synovial tissues, fibroblast-like synovia sites, FLSs, and chondrocytes. The study finds that ZNF667-AS1 is down-regulated in RA, FLSs and LPS-stimulated chondrocytes, and its overexpression promotes cell proliferation and inhibits the production of inflammatory cytokines. Additionally, ZNF667-AS1 overexpression reduces the generation of CD for plus Illinois, 17-plus cells. The study also reveals that ZNF667-AS1 acts as a sponge for MEA, 523-3P, and inactivates the JK to stat signaling, which exerts protective effects during RA development. This article was authored by Qin Zhuo, Lu Wei Yi, Xie Zhen Yan, and others. We are article.tv, links in the description below.