 Microbial inoculants have been used in agricultural practices for over a century, with impressive advancements made in recent decades. These advances include the availability of quality products and elite strains, as well as their ability to reduce costs associated with chemical fertilizer usage. Additionally, microbial inoculants can be used to mitigate environmental impacts from agrochemicals while expanding the application of these products to new regions and crops. However, challenges remain in terms of producing inoculants for a wider variety of crops, as well as expanding the geographic reach of inoculation. Research into innovative microbial solutions for areas subjected to increased environmental stress is needed to further advance the use of microbial inoculants in agriculture. This article was authored by Mariana Sanchez Santos, Marco Antonio Noguera, and Mauriangela Hungria.