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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 3.2: Potentiometric Sensors Charge Screening for a Planar Sensor 01:47 Outline 02:54 Sensitivity of a MOSFET-based potentiometric sensor 04:01 DNA binding and Salt screening 05:32 Salt and screening 10:30 How does a Ion-sensitive Field Effect Transistor work (accumulation) 11:27 ISFET in electrolyte ( accumulation) 13:14 Calculating CDL: screening in 1D 16:27 Centroid of DL charge & capacitance 18:05 Screening in 1D 20:28 At high salt concentration (Gouy-Chapman theory) 23:10 Strong screening (perturbative solution) 24:12 Strong screening (perturbative solution) 25:34 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.