 Pharmacological and surgical treatments of epilepsy can have unsatisfactory outcomes, so a more targeted and on-demand approach is desirable. Here, the authors demonstrate the usage of inhibitory chemogenetics in male non-human primates to attenuate the magnitude and spread of cortical seizures and subsequent body convulsions. This article was authored by Neohiza Miyakawa, Yuji Nogai, Yukiko Hori, and others.