 The study found that papyacid ethanol extract has antibacterial activity against staphilococcus aureus. The optimal formulation of the gel preparation of papyacid ethanol extract was achieved when carbapole 940 and propylene glycol were added at 1.06604 grams and 13.2146 grams respectively. This formulation had good physical properties and stability. This article was authored by Octavianici Andrii and Waiheaning Cediani.