 Colorectal cancer, CRC, is caused by a combination of genetic and environmental factors, including inflammation and oxidative stress, OS. OS is a natural byproduct of metabolism and is also produced by external sources such as cigarette smoke, air pollution, and dietary habits. OS can damage DNA, RNA, and proteins, leading to the activation of inflammatory signaling pathways and the dysregulation of gene and protein expression, which can ultimately result in tumor initiation or cancer cell survival. Additionally, chronic OS can lead to the oxidation of biomolecules, which can further contribute to the development of CRC. Studies have shown that individuals with chronic intestinal diseases such as inflammatory bowel disease, IBD, which are associated with an increased risk of cancer, are more likely to develop colorectal cancer due to their higher levels of OS. This article was authored by Anna Maria Bardelsakova, Jindrick Saltis, and Jan Majiz. We are article.tv, links in the description below.