 This paper presents age-standardized incidence rates per 100,000 for both sexes and by site at national and regional levels of Egypt based on data collected from various sources through the National Cancer Registry Program, NCRP. The results show that liver cancer is the most common site in both sexes, while breast cancer is the second most common among women. By 2050, a three-fold increase in incident cancer relative to 2013 is estimated. These data provide insights into the increased burden of liver cancer and suggest that studying rates of individual sites of cancer may help inform preventive programs. This article was authored by Amal S. Ibrahim, Hussain M. Khaled, Nabil N. H. McLeil, and others.