 This study found that rotavirus had the highest attributable burden of diarrhea in low-income and middle-income countries, followed by norovirus GII, campylobacter SPP, astrovirus, and cryptosporidium SPP. Additionally, the study showed that rotavirus had the highest attributable burden of diarrhea in areas where rotavirus vaccines were not available. This suggests that rotavirus vaccines could play an important role in reducing the overall burden of diarrhea in these regions. This article was authored by James A. Plattsmills, M.D., C.D. Babji, M.D., Ladoporn Bodidata, M.D., and others.