 The Cystic Fibrosis Learning Network, CFLN, is a type of learning health system that uses network organization to improve health and health care. It builds upon existing resources in the CF community and focuses on reliable evidence-based chronic care delivery, as well as creating a system for data-driven collaborative learning. The CFLN has had a positive impact on chronic care processes and indicators of collaborative infrastructure. It has also enabled 36 accredited care centers in the CF Foundation Care Center network to provide timely means to track outcomes, collaboratively plan visits, and involve patient-slash-family partners and QI initiatives. Additionally, almost all CFLN teams have patient-slash-family partners who take ownership of or lead QI initiatives, and 94% of these teams complete 1-13 improvement cycles per month. Overall, the CFLN is a maturing, collaborative infrastructure that fosters interdisciplinary and patient-slash-family partner leadership and the performance of consistent data-driven improvement cycles. This article was authored by Theta Ong, Dana Albin, Rove Esameen and others. We are article.tv, links in the description below.