 Juvenile dermatomyositis, JDM, is a heterogeneous autoimmune inflammatory myositis with symmetrical proximal muscle weakness and a characteristic rash characterized by variable presentation and phenotypes. Detection of myositis autoantibodies is useful in improving JDM diagnosis and predicting the prognosis. This literature review analyzes clinical and autoantibody phenotypes of JDM in four patients hospitalized in one regional center in Ukraine during the last three years, including three who presented during the COVID-19 pandemic. The review shows that anti-synthetase syndrome is common in JDM patients, with anti-PL7 autoantibodies being a significant factor. Further study with more patients and detection of other myositis specific autoantibodies is needed to identify or refute regional features. This article was authored by Oxana Boyerchuk, Anna Kukka, and Irina Yurik.